Sunday, August 22, 2010
Familial occurrence remains the single strongest factor to account for variation in disease risk
This study involving chromosomes substitution strains (CSS) of mice as model organisms tested both the frequency of the affected traits and the strength of their phenotypic effects by observing the genetically inherited phenotypic effects from the father's Y chromosome on female offspring. Because daughters do not inherit their fathers' Y chromosome, any traits that are attributable to the Y must be transgenerational rather than convention! al inheritance. The carefully selected chromosome substitution! method allowed for the control of potentially confounding genetic, social and environmental factors .
"A CSS is made by substituting a single chromosome from a donor strain on an inbred host strain. The resulting strain is identical to the original inbred host strain except for homozygosity for the substituted chromosome"
Daughters (XX) do not inherit the Y chromosome and therefore should not share the phenotype of CSS fathers. However results from this study found that although daughters were genetically identical to females from the host strain, their phenotype is attributed to this transgenerational genetic effect. In this first test for the generality of heritable epigenetic changes, the authors found that the frequency and strength of phenotypic effects resulting from transgenerational and conventional inheritance were comparable in frequency and strength, suggesting that this unconventional mode of inheritance rivals conventional genetics in its impact on biological variation and disease risk.
Wednesday, June 9, 2010
How Do Neurons Become Excited?
Neurons become excited in response to a stimulus. Sensory neurons
are sensitive to specific stimuli in their surrounding environment. For
example, sensory neurons found in human skin are sensitive to touch,
pain, and change in temperature outside of the body. Meanwhile, sensory
neurons located inside the body are sensitive to pain and changes in tem-
perature inside the body. Sensory receptors in the ears, eyes, nose, and
mouth register sound, light, smell, and taste, respectively. Once these
neurons are excited by a stimulus, the excitability or impulse moves along
that neuron toward the brain, where it is interpreted. Our brain initiates
impulses as well. Some of these impulses travel throughout the brain for
thinking processes and memory recall. Or these impulses may travel away
from the brain toward destinations outside the central nervous system
such as skeletal muscle, the heart, and other organs.
Sunday, June 6, 2010
Energy Is Everything
What Is Energy?
Energy may be best understood as a potential or presence that allows for
some type of work to be performed. Some of energy's more recognizable
forms are heat, light, mechanical, chemical, and electrical energy. Without
energy we simply would not exist. The universe, if it existed at all, would
be a frigid, barren, motionless void.
Energy is neither created nor destroyed, however it can be converted
from one form to another. This means that while the total amount of
energy in the universe remains constant, the quantity of the different
forms can change relative to one another. For instance, you are probably
reading this site by the light of a nearby lamp. The light bulb has a thin
filament inside, which transforms the electrical energy running from the
wall socket and through the cord to the filament in the bulb where it
is converted into two other forms of energy—light and heat. As the fila-
ment illuminates, there is a reduction in electrical energy and an increase
in light and heat energies. So energy is not lost but transformed to other
forms.
A little bit closer to nutrition, food contains chemical energy in the form
of carbohydrates, proteins, fats, and alcohol. Once inside our body the
chemical energy of these substances can be transformed into mechanical
energy to power muscular movement and other activities as well as heat
to maintain our body temperature. Furthermore, we can store these
energy molecules when we cannot immediately use them.
Wednesday, May 19, 2010
Sexual health & exercise
Sexual health & exercise
From a healthy living and weight loss perspective, please bear in
mind that both sex and exercise have been proven to help
reduce stress.
If you manage to do both on a regular basis, this should help you stay
relaxed and happy. Exercise also helps increase your sexual desire.
Sometimes, if you have put on weight, you may feel less sexy.
Thursday, May 13, 2010
This exercise is the precursor to seated or bent-over rows performed in the gym.
Scapular Retractions/Rows
The muscles between the scapulas (rhomboids) are most responsible for keeping the shoulders in proper alignment. In a seated or standing position, squeeze your shoulder blades together. A maximum contraction will make the shoulder blades touch. Do not shrug your shoulders and do not arch your lower back. Try this exercise to banish back pain in a prone position as well. Place a pillow or a rolled-up towel under your forehead to keep your neck and spine in a straight line. Lift your shoulders off the surface, squeezing your shoulder blades together, then reach for your feet with your fingertips. Squeeze for five seconds and repeat 20 times. This exercise is the precursor to seated or bent-over rows performed in the gym.
Review Augmentin
Tuesday, March 30, 2010
IODINE This mineral is needed in trace amounts for a healthy thyroid gland
| arthritis home remedies | cleanse herbs |
| diabetes herb |
Saturday, March 27, 2010
Ginseng product Side Effects and Warnings
herbal hair products herbal what kind of pill is this for weight loss healthy weight loss
Sunday, March 14, 2010
I had lost 2.2 pounds and nearly 2% body fat
So I was admittedly a little scared when I had to check in with my trainer last week.
Here's the shocker: I had lost 2.2 pounds and nearly 2% body fat! I completely exceeded my expectations for the first month! I definitely didn't lay off the dessert, so how could this have happened? Somehow my minor changes added up in a big way. Losing weight has always seemed sort of painful for me—something that requires diligence and commitment. But since I lost weight this month without really trying, maybe I was wrong.
Here are three small changes that lead to big results:
1. I added more strength training to my workouts.
I've always been somewhat consistent with strength training, but this month, I increased my workouts with two 50-minute Body Pump sessions each week. I already feel stronger and muscles that I didn't know I had are starting to show. Plus I lost 2% of my body fat, and I know strength training is responsible for most of that.
no-pain-no-gain-scale
2. I cut down on alcohol.
One of my goals for Lose the Dough was to limit the number of cocktails I consumed in one sitting. Last month, I didn't have more than 2 drinks in an evening— and a couple of nights, I skipped the alcohol all together. I kept in mind that a cocktail was a treat and focused on enjoying it instead of slugging it down. I probably cut hundreds of calories from my diet—and it was completely painless!
3. I viewed dessert differently.
I had a few slipups with overdoing it on desserts, but I took my own advice and cut back on the amount and frequency of dessert that I consumed. I'm surprised that I don't miss it as much as I thought I would!
Small changes really do add up, so I'm actually looking forward to my next weigh in. Wish me luck on Month 2!
Commitment to losing weight
Once I made a commitment to losing weight and eating healthier food, I realized that the best way to love my body was by making more nutritious choices. Now a funny little habit of mine has made me realize that food is the best way to show those around me that I love them, too.
Monday through Friday, I wake up with my husband at 6 a.m., even though I don't need to be at work for another four hours. It's not because I'm trying to squeeze in a workout or a sunrise yoga session—it's because I like to make him breakfast. Usually it's a big batch of banana oatmeal for the both of us, and I add all the fixings—like wheat berries, almonds, and a dollop of peanut butter. Being a grown man, my husband is more than capable of cooking himself a healthy breakfast, but I really enjoy helping him start his day off on the right foot. Plus, eating our breakfast together is easily my favorite part of the day.
I never considered myself a nurturing person until I started cooking for my husband. In fact, the act of cooking sort of scared me—mostly because I was terrible at it! Growing up, I never really learned to cook. My mom was a single parent, so the majority of our meals were quick and easy convenience meals—Pop Tarts for breakfast, boxed mac 'n' cheese for lunch, and microwavable meals for dinner—which, of course, weren't the most nutritious foods to eat.
But in my mother's defense, she managed to prepare three meals a day for my sister and me, all while holding down two jobs that had her working more than 50 hours per week. We never complained about what my mom made for dinner. If we did, her response was always the same: "I'm not running a restaurant." She made the effort to put something on the table, which we always appreciated.
food-is-love-oatmeal
My mom planted the seed that even if you're short on time, sitting down for a meal—any meal—is a form of bonding. Over the years I've changed the way that I eat—home-cooked meals instead of frozen fare—and I've realized just how much food is love. I used to focus on low-calorie and low-fat foods—typically ones made with artificial ingredients—but I soon learned that they don't make me feel as good as "real" food does. For instance, an apple with lots of fiber and nutrients satisfies me much more than an apple-cinnamon rice cake. Choosing real foods over fake ones makes me feel like I am choosing to treat my body right. Similarly, picking high quality ingredients for my meals also makes me feel like I am taking good care of myself—and now my husband too.
Thursday, March 11, 2010
Culprit responsible for Type 2 diabete
When we anticipate or smell a meal, the parasympathetic nervous system triggers salivation and increases insulin production in response to the expectation that glucose will be entering the blood stream.
"We think this parasympathetic response is potentially important in type 2 diabetes ," said Vann Bennett, the James B. Duke professor in the departments of cell biology, biochemistry, and neurobiology and Howard Hughes Medical Institute investigator. "Our study showed there is a novel mutation in the gene encoding ankyrin-B, which increases the risk of type 2 diabetes . This happens through an impairment of the insulin secretion that is added by the parasympathetic nervous system."
The study was released online on Tuesday, March 16 in Science Signaling.
Bennett was the first scientist to delineate a molecule called ankyrin and for years has been studying its roles in the heart and brain, as well as other organ systems. Bennett and colleagues discovered the importance of ankyrin-B in the insulin response and the source of a mutation that could lead to diabetes.
In earlier experiments, the group found that pancreatic beta cells that are ankyrin-B deficient display impaired insulin secretion in mice. Ankyrin-B-deficient mice had high blood sugar after eating a source of glucose, but not if the glucose bypassed the mouse's mouth. These findings indicated that ankyrin-B deficiency impaired the parasympathetic chain of events that enhance insulin secretion and had a measurable impact on blood sugar levels.
The scientists then asked whether mutations involving ankyrin-B loss of function were associated with diabetes in humans. They used the American Diabetes Association's GENNID genetic specimen collection from families with type 2 diabetes to genotype 524 people with diabetes disorders and 498 non-diabetic controls. They were searching for three ankyrin-B mutations that had previously been shown in heart muscle cells to create severe loss of function.
They found that one of these mutations of ankyrin-B (R1788W) was associated with type 2 diabetes in about 1 percent of Caucasian and Hispanic individuals. "Genomewide studies have failed to identify more than a small fraction of the genetic heritability in diabetes as well as in other complex diseases," Bennett said. "There are estimates that only 6 percent of the heritability of type 2 diabetes has been detected, by multiple genomewide studies."
Bennett said this implies there is a large reservoir of genes yet to be identified, that are risk factors in type 2 diabetes. "We are excited by our findings of a specific mutation with a known mechanism because of the potential for personalized treatment of diabetes ," he said. "This particular mutation is likely to play a role in 1 percent of adults with diabetes . We hope our finding will lead to strategies to specifically benefit these individuals."
Support for the study came from the Howard Hughes Medical Institute and the American Diabetes Association for management of the GENNID database and DNA samples, as well as a pre-doctoral fellowship from the American Heart Association. The National Institutes of Health also supported the study as did the Swedish Council and the Family Erling-Persson Foundation.
Saturday, February 27, 2010
United States display
Researchers at Tufts University's Friedman School of Nutrition Science and Policy found that around half the dishes served in popular US restaurants delivered more calories than stated on the menu, with some packing double the stated energy value.
And the researchers found discrepancies in the portion sizes the restaurants said they were serving and the actual size of the meal that showed up on the diner's plate, said the study published in the January edition of the Journal of the American Dietetic Association.
The researchers analyzed the calorie content of 18 side dishes and main courses from five popular sit-down restaurant chains -- Applebee's, Denny's, Olive Garden, P F Chang's and Ruby Tuesday -- and 11 sides and main courses from fast food restaurants Domino's, Dunkin' Donuts, McDonald's, Taco Bell and Wendy's.
Ten frozen meals bought at supermarkets were also analyzed.
On average, restaurant foods were found to contain 18 percent more calories than what was stated on the menu, and frozen meals averaged eight percent more calories than stated on their packaging.
"Those don't sound like huge numbers but that really adds up over time," said Susan Roberts, the study's lead author.
"It's the difference between maintaining your weight and gaining 10 pounds," she told AFP.
Some of the restaurant items contained more than twice the calories listed on the menu, including P F Chang's Sichuan-style asparagus.
It delivered 558 calories for a 348-gram serving rather than the 260 calories listed on the menu, according to the testing done by the Tufts researchers.
Frozen dinners fared somewhat better, but even there, three meals -- including from Weight Watchers and Lean Cuisine -- delivered around a quarter more calories than stated on the packet.
Restaurant side orders were among the biggest villains, often bringing more calories to the plate, and eventually the waist, than the main food item of a meal.
To illustrate the gravity of the problem, imagine ordering a veggie-cheese omelet at Denny's with a side of dry toast.
The omelet is listed as being a 340-gram serving with 394 calories, but the dish analyzed in the lab by the Tufts team weighed in at 270 grams and 419 calories.
The seemingly innocuous side dish of dry toast was listed as weighing 28 grams and containing 97 calories.
But the dry toast analyzed by the Tufts team was two-and-a-half times heavier, at 72 grams, and packed 283 calories.
"If you're getting 200 calories more, that's the difference between weight loss and no weight loss," Roberts said.
Roberts was inspired to do the study after writing a book called "The 'I' Diet," which took the results of volumes of research she had done during decades as a nutrition scientist and crafted them into a weight-loss program.
"In the process of doing the book I decided to test the scientific menus on myself. I have two menu tracks: one, you cook everything yourself at home, and I did great on that. Lost lots of weight, it was easy.
"Then I switched over to the supermarket track -- no cooking, just pick up the stuff in the supermarket or, if you go out, eat certain meals. Weight loss completely stopped.
"I came into the lab one day and said, 'Something's not right. I don't believe the numbers in these foods.'"
A second study is being set up to delve more deeply into the truth behind the calorie-counts.